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Human papillomavirus (HPV) is a common sexually transmitted virus. A majority of these infections are asymptomatic. Infection of the cervix by HPV types 16 and 18, the types that cause 99% of cervical cancers, has been found to cause a local inflammatory response including elevated levels of pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8. Moreover, HPV-infected cervical epithelium and peripheral blood mononuclear cells contain phosphorylated p38 mitogen-activated protein kinase (MAPK), which is an important intracellular regulator of the immune response. Here, we demonstrate, using a cervical epithelial cell line, that HPV E6 protein can induce activation of p38 MAPK. Both HPV 16 E6 and E7 transfected cells induced p65 NF-kappaB nuclear localization and phosphorylation. The p65 NF-kappaB subunit is known to bind to the p65-binding site of the HPV 16 E6 gene promoter in vitro, so we suggest that NF-kappaB may also contribute to viral gene transcription through activation of p38 MAPK.RAF Stapleford Tawney
Royal Air Force Stapleford Tawney or more simply RAF Stapleford Tawney was a Royal Air Force station in Essex, UK.
History
Second World War
The station was built by the Ministry of Aircraft Production (MAP), and took part in a number of different roles.
The station was taken over by the RAF in November 1942 to act as a satellite of RAF Mildenhall to act as an aircraft maintenance facility for Hurricane and Spitfire aircraft. It was the first operational base for Hurricanes. As the Hurricane’s range was around 3,000 miles with a 640-gallon drop tank, four of the station’s maintenance bays were converted to carry extra fuel. After the Spitfires
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