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Rheumatoid arthritis (RA) is an inflammatory disease characterized by progressive destruction of the joints. Although tumor necrosis factor-alpha (TNF-alpha) plays a key role in the pathogenesis of RA, the mechanism by which TNF-alpha is activated in RA is not fully understood. The aim of this study was to evaluate the levels of regulatory T cells (Tregs) expressing CD30/CD30L and forkhead box P3 (FOXP3) in RA and investigate their relationship to TNF-alpha levels in the peripheral blood. The levels of CD30/CD30L and FOXP3 were measured by flow cytometry and enzyme-linked immunosorbent assay (ELISA) in peripheral blood mononuclear cells (PBMCs) of 28 RA patients and 28 healthy volunteers. In addition, the relationship between the levels of CD30/CD30L and FOXP3 and the levels of TNF-alpha in the PBMCs was investigated. The levels of CD30/CD30L and FOXP3 were significantly higher in the RA patients than in the healthy controls. Additionally, a positive correlation was observed between the levels of CD30/CD30L and FOXP3. There was no significant correlation between the levels of TNF-alpha and CD30/CD30L or FOXP3. The levels of CD30/CD30L and FOXP3 are increased in the PBMCs of

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